EnvironmentalResponse(Kuchitsu, Nishihama, Takahashi) Community Fluctuation(Sumino)Phenotypic Plasticity(Miyagawa, Akashi) Plant-Animal Interaction(Arimura, Nakajima, Satake) Evolutionary Fluctuation(Tamura, Soma) Tissue FluctuationBrain/Nervous System(Segi) Individual Fluctuation Sex Fluctuation and Chemical Substance Effects (Miyagawa, Satake) DevelopmentalFluctuation(Kondo, Wada)Cellular FluctuationCell Competition and Metabolism(Kon, Sato, Hayata) Mechanobiology(Uemura, Akiyama) Genome/MolecularFluctuation(Shiraishi, Sakamoto, Tamura, Soma)MoleculesGenomeDiverse genetic information/Epigenetic regulationCellsTissues/OrgansIndividualctioCells and FunctionPhysiology, Homeostasis and disease DevelopmentCell differentiation,RegenerationPopulationEcosystemReproductionand SexProduction of next generationAdaptation andEvolutionAcquisition of new functions, speciationInteractionCollaboration and competition with different speciesResearch on adaptive strategies unveiled by biological fluctuations.Strategies for environmental response at multiple levels and biological fluctuationMembersIn response to the challenges of a rapidly changing global environment, this division aims to elucidate the mechanisms of biological fluctuations in living systems. Our novel approach seeks to advance insights into environmental adaptation and diverse biological phenomena, contributing to a sustainable society.Yoshitsugu Akiyama, Masao Uemura Yutaka Sumino, Ushi Nakajima Kazuyuki Kuchitsu, Hiroshi AkashiDirectorProfessor,Department of Biological Science and Technology,Faculty of Advanced EngineeringShinichi MiyagawaPh.D.Future Development Goals Previous research initiatives within the Comprehensive Research Institute, the Division of Agri-Biotechnology (2015-2019) focusing on “food” and the Division of Biological Environment Innovation (2020-2024), which addressed “environment”. These studies highlighted various environmental and societal challenges faced by living organisms, clearly demonstrating that a rapidly changing and harsh environment compels life to adapt for survival and propagation. Under such circumstances, it is an urgent imperative to elucidate the impact of the environment on biological activity and scientifically clarify the fundamental basis for the survival and prosperity of organisms, particularly their strategies for environmental response and of biological diversity. Addressing global environmental issues requires understanding organisms’ inherent adaptive capacity. We have termed the driving force enabling organisms to flexibly respond to diverse internal and external environments, and to adapt by altering their form and function, as “biological fluctuations”. This research division aims to identify and comprehend biological fluctuations across a wide range of biological phenomena, thereby understanding the fundamental principles by which organisms respond and change in adaptation to the environment. This endeavor seeks to generate novel research concepts that will provide insights into resolving contemporary environmental challenges. We define “biological fluctuations” as the driving force enabling organisms to flexibly respond to diverse internal and external environments, adapting through changes in their morphology and function. Biological fluctuations possess the following characteristics:・ “Fluctuations” are observed at all hierarchical levels, including molecular, ・ For instance, developing cells exhibit flexibility; their fate is not solely determined by genome, but guided by environmental sensing and intricate signaling, enabling proper differentiation and adaptation.・ These biological fluctuations varies across species and developmental ・ While appearing unstable, biological fluctuations ultimately contribute to robust macro-scale systems, supporting the production of next-generation evolution, and overall health. We define “biological fluctuations” as the driving force enabling organisms to flexibly respond to diverse internal and external environments, adapting through changes in their morphology and function. Within this division, each member will observe “biological fluctuations” in their respective research areas to elucidate the mechanisms of organisms’ inherent adaptive capacity. We will clarify both unique and common mechanisms of these fluctuations across various species and cells, revealing the specific and universal principles of environmental response. Common research themes include establishing new model systems for biological responses, developing novel analytical techniques, elucidating environmental sensing mechanisms, and clarifying signal transduction, gene expression, and metabolic pathways.Bio and PharmacyTokyo University of ScienceBackgroundObjectivesWhatarebiologicalfluctuations?ResearchActivitiesEstablished: April, 2025To comprehensively elucidate the relationship between the environment and living organisms and to clarify the mechanisms of their adaptive capacity.ObjectivesWe aim to establish a novel scientific discipline based on biological fluctuations, advancing a unified understanding of diverse biological phenomena.cells, tissues, organs, individuals, populations, and ecosystems.stages, even for identical biological phenomena. miyagawa@rs.tus.ac.jp Cellular fluctuations enable responses to internal and external environments, ensuring optimal development, growth, and homeostasis in individuals. Robustness at ecosystem levels is maintained by biological diversity, which represents a form of biological fluctuation. Identifying and clarifying fluctuations at molecular and cellular levels across all biological phenomena will reveal fundamental principles of environmental response, providing pathways to resolve contemporary environmental challenges. Biological fluctuations are phenomena observed across different hierarchical levels: molecular, cellular, tissue/organ, individual, population, and ecosystem. This research division will categorize these into four groups: ① Molecular, ② Cell/Tissue/Organ, ③ Individual/Population, and ④ Ecology/Evolution, with each group advancing the elucidation of the molecular basis of life fluctuations. Emphasis will also be placed on interactions between different hierarchical levels to unveil robust environmental response capabilities that are unpredictable from the behavior of individual components.◦ Molecular levelMembers: Shu Kondo, Mitsunori Shiraishi, Naoyuki Wada, Takuya Sakamoto ◦ Cellular/Tissue/Organ levelMembers: Eri Segi, Masayoshi Hayata, Satoshi Sato, Shunsuke Kon, ◦ Individual/Population levelMembers: Shinichi Miyagawa, Genichiro Arimura, Shinichi Satake, ◦ Ecology/Evolution levelMembers: Fuminori Takahashi, Koji Tamura, Akiko Soma, Ryuichi Nishihama, 16Division of Biological Fluctuations
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