26Future Development GoalsEstablished: April, 2021Our mission is to transcend traditional brain research and technology development, which often focuses on individual subjects. Instead, we aim to forge a new frontier in brain science—an area that delves into the intricate interactions among multiple brains.We’ll host open seminars and workshops, fostering a shared language among researchers in diverse fields. Our aim is to educate young investigators and students while enhancing collaboration and integration among researchers.Objectives takemura@rs.tus.ac.jp(Segi and Oguro-Ando [University of Exeter])・Investigationofcross-speciesvocalcommunication(Ichikawa, Saito, and Yamada)・Examinationofcross-speciesvocalcommunication:Relationshipbetweenultrasonicvocalizationsinmiceandtheeffectsofultrasoniclisteninginhumans(Ichikawa, Saito, Yamada, and Asakura)・AnalysisofStress-InducedDepression-likeState(Saito, Yamada, Takemura, and Yamamoto)・StudyontheRelationshipbetweenHumanGaitBehaviorandPersonalityTraits:ExtractionandEvaluationofGaitCharacteristicsDerivedfromHumanInternalState(Ichikawa, Takemura, and Yamamoto)・BiomechanicalAnalysisofAge-DependentGaitDeficiencyinCerebellarNeuralTransmissionDeficientMice(Hagiwara, Takemura, and Yamamoto)・Evaluationoftheneuralbasisofstresssensitivityinsynapticprotein-deficientmice(Hagiwara, Saito, Yamada, Takemura, and Yamamoto)・AnalysisofJakmip1-deficientmice,amousemodelforautism(Saito, Oguro-Ando, Hagiwara, Yamada)・DNAmethylationanalysisinvariousmousemodels(Oguro-Ando, Segi, Saito, Hagiwara, Yamada)・Elucidationofbrainfunctionsthatregulatesocialbehavior'Evaluationofsocialbehaviorandbraindevelopmentalchangesinahumanchromosomedeletiondiseasemodelofautism'(Segi-Nishida and Oguro-Ando)・Examinationofcross-speciesvocalcommunication:Relationshipbetweenultrasonicvocalizationsinmiceandtheeffectsofultrasoniclisteninginhumans(Ichikawa, Saitoh, Yamada and Asakura)・Analysisofstress-induceddepression-likestate(Saitoh, Yamada, Takemura, and Yamamoto)・Physiologicalchangesduetopleasantemotionalexperiencesandpositiveperceptionofotherpeople'sfacialexpressions(Ichikawa and Oguro-Ando)・Biomechanicalanalysisofage-dependentgaitdeficiencyinmicedeficientincerebellarneuraltransmission(Hagiwara, Takemura and Y. Yamamoto)・Evaluationoftheneuralbasisofstresssensitivityinsynapticprotein-deficientmice(Hagiwara, Saitoh, Yamada, Takemura, and Y. Yamamoto)・AnalysisofJakmip1-deficientmice,amousemodelforautism(Saitoh, Oguro-Ando, Hagiwara, and Yamada)・DNAmethylationanalysisinvariousmousemodels(Oguro-Ando, Segi-Nishida, Saitoh, Hagiwara, and Yamada)・UnveilingEmotionalResonanceinClassicalMusicThroughBrainwaveAnalysis(Asakura, and Hasegawa)・ResearchonCausalityAnalysisTechnologyBetweenVariousBiologicalSignalsforVisualizationofBrain-GutCorrelationPhenomenon(Sakata)BackgroundandpurposeofthedivisionResearchOrganizationandMembersOngoingResearchTopicsOur division unites researchers from both within and beyond the university, focusing on brain science, neural information, and systems. Our mission is to pioneer the groundbreaking academic field known as ‘Parallel Brain,’ which originates from Tokyo University of Science. We strive to uncover the intricate interactions of brain activity among multiple individuals.DirectorProfessor, Department of Mechanical and Aerospace Engineering,Faculty of Science and TechnologyDoctor of Engineering In the 21st century, neuroscience (brain science) is rapidly evolving. People anticipate that maintaining brain health will enhance quality of life in an aging society, while leveraging brain information processing mechanisms will drive innovative technologies. With most things now connected to the Internet (IoT: Internet of Things) and wearable devices seamlessly linking humans to the digital realm (IoB: Internet of Bodies), It is not far-fetched to envision a future where human minds connect to the Internet (IoM: Internet of Minds). This marks the dawn of the Internet of Brains. Our division aims to create an interdisciplinary research platform, pooling expertise and neural information to pioneer the academic field of ‘Parallel Brain’ at Tokyo University of Science, in anticipation of the forthcoming Internet of the Brain era. Within our research organization, we propose cutting-edge technology for sensing and replicating biological information. By synchronously measuring the brains of multiple individuals—both mice and humans—we forge an original interdisciplinary field of brain research. Our division’s mission is twofold: to unravel the mechanisms behind group formation and symbiosis in social spaces, and to establish a theoretical framework describing interactions among social animals’ multiple brains. Leveraging common sensing technology across mouse and human experiments, we operate in three distinct groups, synergistically driving emergent results.Animal Experiment Group (Mouse/Human): This group delves into multidimensional brain research, exploring cognition-related aspects such as depression (characterized by pessimistic cognition), senile dementia (with impaired cognition and memory functions), and autism (involving impaired social cognition and communication). From molecular and neural circuits to animal models, we aim to elucidate underlying mechanisms and lay the groundwork for improved drugs and diagnostic agents.Sensing Group: Focused on brain dysfunction related to personality traits, this group analyzes gaze behavior and physiological indicators in developmental disorders. Our goal is to develop measurement technologies and assistive devices that enhance understanding and support.Mathematical Model Group: Here, we construct models and theories for brain information processing systems. Drawing insights from multidimensional studies—including functional brain imaging and cognitive psychology experiments—we emphasize human social correlation. The division consists of 18 researchers in interdisciplinary neuroscience-related fields, including the Faculty of Science and Technology (Hiroshi Takemura, Takeo Ushijima, Takahiko Yamamoto, Akari Hagiwara, Takumi Asakura, Masataka Yamamoto), the Faculty of Pharmaceutical Sciences (Akiyoshi Saito, Daisuke Yamada), the Research Institute for Biomedical Sciences (Takeshi Nakamura, Shingo Koinuma), the Faculty of Engineering (Osamu Sakata, Takuya Hashimoto), the Faculty of Advanced Engineering (Eri Segi (Nishida), Kanzo Suzuki), the Institute of Arts and Sciences (Hiroko Ichikawa), and three visiting researchers: Ryohei Hasegawa and Toshihiro Takamatsu from the National Institute of Advanced Industrial Science and Technology (AIST) and Asami Oguro-Ando from the University of Exeter Medical School. We are mainly engaged in collaborative and cooperative research use of the unique talents and strengths of each member. The following is a port of list of ongoing collaborative research projects that transcend the boundaries of each specialized field, which are possible only in this division. For details, please see the division's website.・ElucidationofbrainfunctionscontrollingsocialbehaviorHiroshi TakemuraUnlocking the Next Era: The Internet of Brains (IoB) in the Next-Generation Brain ProjectParallel Brain Interaction Sensing Division
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