生体機能メカニズム解明分子↓↑神経↓↑脳↓↑個体薬物生体標的分子慢性腰痛モデルの確立痛み改善時の神経回路・分子メカニズムの解明腰痛の劇的改善へ治療効果（抗うつ効果）病態（うつ）病因（ストレス）OpenInnovationProjectThis open innovation project is a joint research project between Kao Corporation (“Kao”) and the Tokyo University of Science (TUS). This is the first project designated under the “Open Innovation Projects” system of the RIST. Kao and TUS are both working to solve social problems through science and technology, and we expect significant synergy effects through collaborative research and development.DirectorAssociate Professor, Department of Pure and Applied Chemistry, Faculty of Science and TechnologyFuture Development GoalsKao will promote the development of innovative technologies to enrich peopleʼs lives by collaborating with Kaoʼs technologies and the TUSʼs knowledges in biochemical science, interface science, and brain science.We will work not only on research and development, but also on contributions to the SDGs and human resource development. Details of these efforts can be found in the movie※ at TUS Forum 2021 (Japanese only).※URL: https://www.tus.ac.jp/tusforum/2021/archive.html#point03Objectivesテテーーママ１１：：ババイイオオデデババイイススのの革革新新的的開開発発テテーーママ２２：：泡泡立立ちち制制御御技技術術のの革革新新的的開開発発Established: April, 2022 koho@admin.tus.ac.jp35Theme 4 : Innovative development of localized technology of cellulose nanofiber reinforced resin in carbon fiber reinforced plastics(CFRP) Based on educational philosophy of TUS, “Innovation in Science and Technology for Sustainable Development”, TUS aims to solve various problems in society through education and research. In addition, Kao Group Mid-term Plan 2025 (K25) outlines the company’s direction to “Become a company that protects future lives” and Kao conducts research and development to contribute to sustainable society and realization of a rich lifestyle culture. Thus, Kao and TUS expect significant synergy effects from the collaboration for Kirei—Making Life Beautiful. Therefore, we have established the “The Kao “Kirei” Future Open Innovation Project” and started joint research. While recognizing their respective social missions and roles, both parties are promoting the development of innovative technologies to enrich people’s lives. The following four joint research themes are in progress. We aim to contribute to the areas of “Ecology”, “Life” and “Everyday lives” through the research and development of each research theme.Theme 1: Research on biofuel cells and biosensorsTheme 2: Research on foaming control and functionalizationTheme 3: Research on neural and molecular mechanisms of painTheme 4: Research on application of cellulose nanofiber reinforced resin Theme 1Research on Biofuel Cells and BiosensorsInnovative development of bio-devices1) Investigation of the practical application of health monitoring devices that 2) We will study the realization of an ultimate health care device that allows anyone to manage health information at any time by incorporating biofuel cells, which provide clean and safe power supply regardless of location, into wearable devices.Theme 2Research on foaming control and functionalizationInnovative development of foaming control technology1) Maximize surfactant performance using small amounts of polymers to 2) Understand the synergistic effects of mixing surfactants and polymers to composites to structural materialsgenerate power from the human bodyachieve comfortable and rich foam with a minimum of materialscreate technologies that can control various foam performancesTheme 3Research on Neural and Molecular Mechanisms of PainInnovative development for improvement of low back pain1) Elucidation of neural and molecular mechanisms of chronic low back pain2) Elucidation of the mechanism of stress-induced aggravation of low back pain and search for treatment methods by modulating brain functions Through the above, we aim to clarify the relationship between the onset of low back pain and stress, and to improve low back pain by regulating brain functions.Theme 4Research on Application of Cellulose Nanofiber Reinforced Resin Composites to Structural MaterialsResearch on innovative development of CNF reinforced resin composites for internal localization in carbon fiber reinforced Plastics (CFRP)1) Explore the application of CNF-reinforced resin composites for high interlaminar toughness of CFRP composite laminates.2) Explore material design guidelines for the application of CNF-reinforced resin composites as structural materials. In addition to research and development on the above existing themes, discussions are held on the establishment of new themes. In order to discuss new themes, we will hold a new technology presentation to introduce the TUS’s technological seeds. Brainstorming sessions are also planned to discuss the expansion and development of research and development into new areas. In addition, we also offer special lectures for undergraduate and graduate students and other human resource development programs to expand organization-to-organization collaboration.人体から発電するヘルスモニタリングデバイスの実用化に向けた検討テテーーママ３３：：腰腰痛痛改改善善ののたためめのの革革新新的的開開発発Develop innovative technologies to enrich people’s livesIsao ShitandaThe Kao “Kirei” Future Open Innovation Project
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