HistoryandBackgroundofThisDivisionResearchPurposesandGoalsofThisDivisionMembersandTheirRolesinThisDivisionCell-based therapy and regenerative medicine can be greatly accelerated by applying the concept of drug delivery system (DDS), i.e., drug delivery at the right time, at the right site of action, and in the right amount, to cells that are administered to patients for disease treatment. This division aims at developing “superior cells” whose functions are extremely upregulated and DDS that improves their functions.Figure 1 Members and roles of each group.DirectorProfessorDepartment of PharmacyFaculty of Pharmaceutical SciencesPh.D.22Future Development GoalsEstablished: April, 2021To develop “superior cells” and DDS that can precisely control the function and in vivo fate of the cells for accelerating regenerative medicine.To create a novel and unique research field focusing on “superior cells” by collaboration of researchers with a variety of expertise.Objectives makiya@rs.tus.ac.jp This division has a root in the DDS Research Division established in the Research Institutes for Science and Technology, Tokyo University of Science in 2003. In “Fusion of Regenerative Medicine with DDS Division” started from 2015, researchers headed by Professor Kimiko Makino have conducted collaborative researches focusing on regenerative medicine and the development of DDS for intractable diseases. To continue these activities, a predecessor round-table conference on Superior Cells and DDS Development for Regenerative Medicine was founded on 2020, which has been re-established as a division in April 2021. Under the overall goal of accelerating cell-based therapy and regenerative medicine, this division is focusing on (1) the development of “superior cells” by functionalizing the cells administered to patients for therapeutic purposes, and (2) the development of DDS that can precisely manipulate the in vivo distribution of cells and other functional molecules. The research purposes also include the development of therapeutic modalities against respiratory, brain, immune, cancer, and bone diseases. The four groups below cooperate with one another to accelerate the group research.(1) Superior cell/DDS development groupThis group designs and constructs superior cells, and develops DDS aiming at controlling the function and in vivo distribution of cells and other functional bioactive molecules. A goal is to develop “superior cells” that super-exceed the existing cells in terms of cellular functions through (1) the addition of novel functions, (2) the development of multicellular spheroids/organoids, and (3) the use of exosomes and other extracellular vesicles. In addition, various delivery systems are developed and applied to the superior cells and their usefulness is examined in animal models.(2) Cell function regulation system development groupThis group creates novel compounds that regulate cellular functions, and functional materials that can be used in cell-based therapy and regenerative medicine. These compounds and materials are supplied to other groups for applications and analysis. The data obtained using them are used for the development of more functional compounds/materials.(3) Physical property control/analysis groupThis group evaluates the physical properties of the items developed by the superior cell/DDS development group and the cell function regulation system development group, including superior cells, delivery systems, and functional compounds/materials. This group supports the optimization of these items by data feedback to the corresponding groups.(4) Cell/tissue regeneration groupThis group investigates the mechanisms of the regeneration of the lung, bone and other tissues, and treat the diseases of these tissues/organs. The interaction of superior cells/DDS and the immune systems is also analyzed. Figure 1 summarizes the members and roles of each group. This division develops superior cells and DDS regenerative medicine by constructing organic interrelationships among the members of the division in pursuit of a new-stage collaboration.Development of superior cells and DDS for accelerating regenerative medicineMakiya NishikawaDevelopment of superior cell and DDS for regenerative medicine
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